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| First Name: | A.Baki | | Last Name: | Agbas | | Title: | Associate Professor | | Advanced Degrees: | MSc, PhD | | Affiliation: | Kansas City University of Medicine and Biosciences | | Department: | Biochemistry | | Street Address 1: | 1750 Independence Avenue | | City: | Kansas City | | State/Province: | MO | | Zip/Postal Code: | 64106 | Country/Territory: | U.S.A. | | Phone: | 816-654-7614 | | Fax: | 816-654-7611 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 24 June 2011]
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Aging Process, Neuromuscular Disorders (ALS, etc.), Alzheimer Disease, Parkinson Disease
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Molecular and Cell biology, Neurotransmission, Protein structure/chemistry, Neurobiology, Oxidative Stress, Signal transduction
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Abdulbaki (Baki) Agbas, MSc, Ph.D., became a KCUMB faculty member in early 2010 after working as a Research Assistant Professor at the Higuchi Biosciences Center and a faculty member of the Department of Pharmacology and Toxicology at the University of Kansas in Lawrence, Kansas.
He earned a master of science in clinical biochemistry in 1985 at Ataturk University in Erzurum, Turkey. He completed his doctor of philosophy in biochemistry at the University of Szeged in Hungary, and a university docent in medical biochemistry with The Council of Higher Education in Turkey.
Dr. Agbas' research interests include molecular biology of aging and aging related neurodegenerative diseases. He has published research on key proteins in the central nervous system that undergo oxidative modifications during brain aging. He recently studied Calcineurin and Cu/Zn Superoxide dismutase interactions in Amyotrophic Lateral Sclerosis (ALS) disease. Currently, he is studying the physiological and biochemical changes in mitochondria in a transgenic mouse model that endogenously expresses excessive glutamate. He is also studying Zinc homeostasis in mitochondria of ALS model mice and may be extending his studies to zebra fish as a proposed animal model for ALS related studies.
Dr. Agbas' career highlights include being designated a fellow for the United Nations Educational, Scientific and Cultural Organization to study modern concepts in biology at the Biological Research Center in Szeged, Hungary, and discovering a novel mRNA binding protein in neuronal cell. |
3. E.K. Michaelis, X. Wang, R.Pal, X.Bao, K.N. Hascup, Y.Wang, W.T. Wang, D. Hui, A.Agbas, I.Y. Choi, A.Belousov, and G.A. Gerhardt (2011) Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: Increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression. Neurchem.Int., doi: 10.1016/j.neuint.2011.03.003
4. Xinkun Wang, Xiaodong Bao, Ranu Pal, Abdulbaki Agbas, Elias K Michaelis . (2010)Transcriptomic responses in mouse brain exposed to chronic excessof the neurotransmitter glutamate. Genomics 11: 360-379
5. Bao,X., Pal, R Hascup, K.N., Wang, Y., McKerchar, T., Xu, W., Hui, D., Agbas, A., Wang, X., Pinkston, J., Fowler, S.C., Michaelis, M.L., Belousov, A., Gerhardt, G.A., and Michaelis, E.K. (2009) Transgenic expression of glutamate dehydrogenase 1 (Glud1) in neurons: In vivo model of enhanced glutamate release altered synaptic plasticity, and selective neuronal vulnerability. J Neurosci. 29(44):13929-44.
6. Abdulbaki Agbas and Jackob Moskovitz. (2009)The role of methionine oxidation/reduction in the regulation of immune response. Current Signal Transduction Therapy 4(1): 46-50
7. D.Hui , K.N. Kumar, J.R. Mach, A.Srinivasan, R.Pal, X. Bao, , A.Agbas, G.Hofner, K.T. Wanner, and E.K. Michaelis (2009) A Rat Brain Bicistronic gene with an internal ribosome entry site codes for a phencyclidine-binding protein with cytotoxic activity J.Biol.Chem., 284(4):2245-2257
8. Agbas,A, Hui,D., Wang,X., Tek,V., Zaidi,A., and E.K. Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. (2007) Biochem.J. 405(1): 51-59
9. A.Agbas, A.Zaidi, and E.K. Michaelis.(2005) Decreased activity and increased aggregation of brain calcineurin during aging. Brain Res., 140: 120-126
10. Pal, Ranu, Agbas, Abdulbaki, Bao, Xiaodong, Hui, Dongwei, Leary, Cynthia, Hunt, John, Bechtel, Misty, Naniwadekar, Ashutosh, Michaelis, Mary L., Kumar, Keshava N., and Michaelis, Elias K. (2003) Selective Dendrite-Targeting of mRNAs of NR1 Splice Variants without Exon 5: Identification of a cis-Acting Sequence and Isolation of Sequence-Binding Proteins. Brain Res., 994:1-18
11. Agbas, A., Chen, X., Hong, O., Kumar, K.N., and Michaelis, E.K. (2002) Superoxide modification and inactivation of a neuronal receptor-like complex. Free Radical Biology & Medicine, 32(6): 512-524
12. Zhang, X., Fei, K., Agbas, A., Yan, L., Zhang, J., O’Reilly, B., Deutzmann, R., and Sarras, MP., Jr. (2002) Structure and function of an early divergent form of Laminin in hydra: a structurally conserved ECM component that is essential for epithelial morphogenesis. Dev.Genes Evol. 212: 159-172
13. De Lisle, RC., Petitt, M., Huff, J., Isom, KS., and Agbas, A. (1997) MUCLIN expression in the cystic fibrosis Transmembrane conductance regulator knockout mouse. Gastroenterology, 113: 521-532
14. Agbas, A., Ahmed, MS., Millington, W., Cemerikic, B., Desiderio, DM., Tseng, JL., and Dass, C. Dynorphin A(1-8) in human placenta. Amino acid sequence determined by Tandem Mass Spectrometry. (1995) Peptides, 16(4): 623-627
15. Sarras, MP., Jr., Yan, L., Grens, A., Zhang, X., Agbas, A., Huff, JK., St.John, PL., and Abrahamson, DR. (1994) Cloning and biological function of laminin in Hydra vulgaris. Develop. Biol. 164: 312-324
16. Agbas, A., and Sarras, MP. Evidence for cell surface extracellular matrix binding proteins in Hydra vulgaris. (1994) Cell Adhesion and Commun. 2: 59-73
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